Human Oncostatin-M-specific receptor subunit beta(OSMR)

Oncostatin M receptor (OSMR) is a protein that belongs to the type I cytokine receptor family. It forms complexes with other proteins such as interleukin 6 signal transducer and interleukin 31 receptor A, and plays a role in the signaling of oncostatin M and interleukin 31.

OSMR is expressed in various non-blood-forming cells and organs, including the liver, mesothelial cells, glial cells, and mammary glands. It has been shown to be induced by parathyroid hormone in osteoblasts and by oncostatin M in fetal hepatocytes. OSMR has been linked to primary cutaneous amyloidosis and plays a role in bone turnover.

A lack of OSMR activity has also been associated with adipose tissue inflammation and insulin resistance preceding obesity, and OSM signaling through OSMR is involved in the regulation of hematopoiesis.