Specification
| Alternative Names | CCR8 |
| Uniprot ID | P51685 |
| Tag | Tag-Free |
| Size | 1 vial contains approximately 5x106 cells in 1 ml |
| Screening Marker | Puromycin |
| Culture Media | RPMI 1640 + 10% FBS + 10μg/mL Puromycin |
| Buffer | 35% FBS + 55% RPMI 1640 + 10% DMSO |
| Tested Application | Binding assay by FACS and cell based ELISA. |
| Storage | Frozen in liquid nitrogen or stored at -80°C |
Background
| Function | Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | |
| Protein Family | G-protein coupled receptor 1 family |
| References | Functions Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380 Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537 High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905 findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351 Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |