Specification
| Alternative Names | CCR8 |
| Uniprot ID | P56484 |
| Tag | Tag-Free |
| Size | 1 vial contains approximately 5x106 cells in 1 ml |
| Screening Marker | Puromycin |
| Culture Media | F-12K + 10% FBS + 6μg/mL Puromycin |
| Buffer | 35% FBS + 55% F-12K + 10% DMSO |
| Tested Application | Binding assay by FACS and cell based ELISA. |
| Storage | Frozen in liquid nitrogen or stored at -80°C |
Background
| Function | Receptor for the CCL1/SCY1/TCA-3 chemokine. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in thymus. |
| Protein Family | G-protein coupled receptor 1 family |
| References | Functions CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin. PMID: 25344933 Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PMID: 24714157 A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells. PMID: 23798714 Expression of CCR-8 in microglia was upregulated in the presence of CCL-1. PMID: 23747724 C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563 |
QC Data
| Please contact us for specific QC data. |