Anti-Human HER2 (Trastuzumab)

Specification
Target HER2
Clone Trastuzumab
Isotype Human IgG1-Kappa
Expression System CHO
Purification Protein A
Recommended Isotope Control Anti-HEL Human IgG1-Kappa Isotype control
Recommended Dilution Buffer PBS, pH 7.8
Formulation PBS, pH 7.4,Contains no stabilizers or preservatives
Endotoxin <1EU/mg Determined by LAL gel clotting assay
Purity >95% Determined by SDS-PAGE
Sterility 0.2 μM filtered
Storage This antibody can be storaged at 2°C to 8 °C for 2 weeks under sterile conditions;-20°C for 3 months under sterile conditions;-70°C for 36 months under sterile conditions.Avoid repeated freeze-thaw.
Disclaim For Research Use Only
Background
Background Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody 6 that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast cancer, where there is a proven amplification of the HER-2 oncogene or over-expression of the HER-2 protein in tumours. It is suggested that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and elevated activation of HER2 triggers multiple downstream pathways leading to abnormal proliferation of cancer cells . Trastuzumab binds to HER2 and suppresses cancer cell growth, proliferation, and survival directly and indirectly
QC Data
Please contact us for specific QC data.
$0.00
In stock
SKU
EB-EB006

Various size from 1 mg to 104 mg available. Please inquiry us first for the price and availablity.

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